Limited postdoctoral positions are available in 2013. We have an urgent need for a Ph.D with experience in protein purification (Akta use) and crystallography; recent PhD and US residency required (for training grant). Other postdoc positions require the ability to obtain your own support through postdoctoral grant applications. For these we are looking for protease enzymologists; cell biologists interested in secretory protein biology (i.e. brain and pancreas); or bone cell biologists interested in FGF23 metabolism. Please email a cover letter and your CV (with the names of three references) to ilind001@umaryland.edu.
We also have openings for graduate students. If you would like to rotate in the lab (you must be currently enrolled in a University of Maryland graduate program) please send an email to Iris Lindberg at ilind001@umaryland.edu.
Here was our former ad for Postdoctoral Positions which contains more information:
POSTDOCTORAL POSITIONS AVAILABLE IN BALTIMORE
Independent, motivated individuals with experience in either molecular biology/cell biology or protein purification/enzymology and an interest in secretory systems are sought for work in an established neurobiology/endocrinology laboratory at the University of Maryland School of Medicine in Baltimore. The laboratory is focused on understanding the regulation of peptide hormone and neuropeptide synthesis in the secretory pathway. We study the maturation enzymes known as proprotein convertases, responsible for generating most secreted signaling proteins, and implicated in diseases such as diabetes, obesity, bone disease, and cancer. We also study small secretory chaperones, which participate not only in convertase maturation but also in blocking protein aggregation in the secretory pathway. One project involves the study of prohormone convertase biochemistry and dominant negative effects (effects of oligomerization, the role of the inhibitory tail domain, and cellular targeting); this person may also be involved in characterizing novel synthetic inhibitors developed by our collaborators in vitro and in cell culture for effects on peptide hormone synthesis. Confocal microscopy of convertases and known disease-related human convertase mutants in cells and tissues will be used to shed light on subcellular targeting mechanisms. Two other projects involve further work on secretory chaperones; and the elaboration of bone secretory biology with respect to FGF23 maturation and secretory chaperones, an exciting system in which secretory pathways are modulated during the osteoblast to osteocyte transition.
The convertase project is highly relevant to obesity since PC1/3 has been found to be the third most important gene contributing to monogenic obesity. The secretory chaperone project is relevant to Alzheimer’s; in particular, the mechanism by which amyloid plaques develop in brain tissue. The FGF23 project is relevant to many inherited human bone diseases, such as XLH, ADHR, TIO, and others.
Please visit the lab website http://thelindberglab.com for more information on the various laboratory projects.
Please email a CV containing your research expertise, a brief statement of your research interests, and the email addresses and phone numbers of three references, to Dr. Iris Lindberg at ilind001@umaryland.edu. A published or submitted first-author paper in a refereed English-language journal is required to be considered for this position; ability to participate in an NIH training grant is highly desirable.
