Publications – Iris Lindberg

Please find below recent publications from the Lindberg laboratory and selected collaborative papers.

  • 7B2 chaperone knockout in APP model mice results in reduced plaque burden.
    Jarvela T., Womack, T., Georgiou,P., Gould, T., Eriksen, J.L., and Lindberg, I. (2018) Scientific Reports Jun 28;8(1):9813. doi: 10.1038/s41598-018-28031-7. PMID:29955078
  • Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.
    Winters A, Ramos-Molina B, Jarvela TS, Yerges-Armstrong L, Pollin TI, and Lindberg, I. (2017). Diabetes Res Clin Pract. 2017 Jul 3;131:82-90. doi: 10.1016/j.diabres.2017.06.023. [Epub ahead of print] PMID:28719828.
  • The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.
    Jarvela, T.S., Lam, H.A., Helwig, M., Lorenzen, N. Otzen, D.E., McLean,P.J., Maidment, N.T. and Lindberg, I. (2016). Proc Natl. Acad. Sci. 113(32):E4708-15. PMID:27457957 .
  • PCSK1 variants and human obesity. (Review)
    Ramos-Molina, B. Martin, M.G. and Lindberg, I. (2016). in Genetics of Monogenic and Syndromic Obesity,Progress in Molecular Biology and Translational Science, P. Michael Conn, Ed. Academic Press Vol 140, 47-74
  • Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition.
    Yamamoto, H., Ramos-Molina, B., Lick, A.N., Prideaux, M., Albornoz, V., Bonewald, L. and Lindberg, I. (2016) Bone, 84:120-30
  • Chaperones in Neurodegeneration. (review of minisymposium)
    Lindberg, I., Shorter, J., Wiseman, R.L., Chiti, F., Dickey, C.A., McLean, P.J. (2015) J. Neuroscience, Oct 14;35(41):13853-9. doi: 10.1523/JNEUROSCI.2600-15.PMID:26468185 .
  • Revisiting PC1/3 mutants: dominant-negative effect of endoplasmic reticulum-retained mutants.
    Blanco, E.H., Ramos-Molina, B., Lindberg, I. (2015) Endocrinology 156(10):3625-37.
  • Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors.
    Ramos-Molina B, Lick AN, Blanco EH, Posada-Salgado, J.A., Martinez-Mayorga, K., Johnson, A.T., Jiao, G.S., Lindberg, I. (2015) Biochem Pharmacol. pii: S0006-2952(15)00254-3.
  • Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
    Ramos-Molina, B., Lick, A.N., Nasrolahi Shirazi, A., Oh, D., Tiwari R., El-Sayed, N.S., Parang, K., Lindberg, I. (2015) PLoS One. Jun 25;10(6):e0130417. doi: 10.1371/journal.pone.0130417. eCollection 2015
  • Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation.
    Ramos-Molina B., Lindberg I. (2015) Mol Endocrinol. May;29(5):756-64.

  • FGF23 is endogenously phosphorylated in bone cells.
    Lindberg, I., Pang, H.W., Stains, J.P., Clark, D., Yang, A.J., Bonewald, L., and, Li, K.Z. (2014) J Bone Miner Res. Sep 6. doi: 10.1002/jbmr.2354. [Epub ahead of print]
  • Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph.
    Blanco, E.H., Peinado, J.R., Martín, M.G., and Lindberg, I. (2014) Endocrinology 155(9):3434.
  • Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.
    Prabhu, Y., Blanco, E.H., Liu, M, Peinado, J.R., Wheeler, M., Gekakis, N., Arvan, P. and Lindberg, I. (2014) Endocrinology Jul;155(7):2391-401.
  • Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS.
    Peinado, J.R., Sami, F., Rajpurohit, N., and Lindberg, I. (2013) FEBS Lett., Nov 1;587(21):3406-11 PMID: 24042052
  • Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus.
    Yourshaw, M., Solorzano-Vargas, R.S., Pickett, L.A., Lindberg, I., Wang, J., Cortina, G., Baron, H., Nelson, S.F., and Martín, M.G. (2013) J. Pediatric Gastroenterology & Nutrition. 57:759-67. PMID: 24280991
  • A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer’s disease.
    Hoshino, A., Helwig, M., Rezaei, S., Berridge, C., Eriksen J.L., Lindberg, I. (2014) J Neurochem. 2014 Feb;128(3):419-30. doi: 10.1111/jnc.12454. Epub 2013 Oct 24.
  • Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort.
    Martín MG, Lindberg I, Solorzano-Vargas RS, Wang J, Avitzur Y, Bandsma R, Sokollik C, Lawrence S, Pickett LA, Chen Z, Egritas O, Dalgic B, Albornoz V, de Ridder L, Hulst J, Gok F, Aydoğan A, Al-Hussaini A, Gok DE, Yourshaw M, Wu SV, Cortina G, Stanford S, Georgia S. (2013) Gastroenterology Jul;145(1):138-48. doi: 10.1053/j.gastro.2013.03.048. Epub 2013 Apr 2
  • The Neuroendocrine Protein 7B2 Suppresses the Aggregation of Neurodegenerative Disease-related Proteins.
    Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, Eriksen JL, and Lindberg I. (2013) J Biol Chem. 2013 Jan 11;288(2):1114-24. doi: 10.1074/jbc.M112.417071. Epub 2012 Nov 21. PMID:23172224
  • Functional Consequences of a Novel Variant of PCSK1.
    Pickett LA, Yourshaw M, Albornoz V, Chen Z, Solorzano-Vargas RS, Nelson SF, Martín MG, and Lindberg I. (2013) PLoS One. 8(1):e55065. doi: 10.1371/journal.pone.0055065. Epub 2013 Jan 28.PMID:2338306 [PubMed – in process]
  • Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study.
    Yongye, AB, Vivoli, M, Lindberg, I, Appel, JR, Houghten, RA, Martinez-Mayorga K. PLoS One. 2013;8(2):e56957. doi: 10.1371/journal.pone.0056957. Epub 2013 Feb 22. PMID: 23451118
  • The Neuroendocrine Protein 7B2 Is Intrinsically Disordered (2012)  Dasgupta I, Sanglas L, Enghild JJ, and Lindberg I. (2012) Biochemistry. 2012 Sep 25;51(38):7456-64. doi: 10.1021/bi300871k. Epub 2012 Sep 14.
  • Hexa-D-Arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. (2012)
    Yuan B, Feng JQ, Bowman S, Liu Y, Blank RD, Lindberg I, Drezner MK.J  Bone Miner Res. Aug 9. doi: 10.1002/jbmr.1738. [Epub ahead of print]
  • Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine Derivatives. (2012) Vivoli M, Caulfield TR, Martínez-Mayorga K, Johnson AT, Jiao GS, Lindberg I. Mol Pharmacol.  Mar;81(3):440-54.
  • Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis (2011)  Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I. J Biol Chem.  Dec 9;286(49):42504-13.
  • Processing of Proaugurin Is Required to Suppress Proliferation of Tumor Cell Lines. Ozawa A, Lick AN, Lindberg I. (2011) Mol Endocrinol. Mol Endocrinol.  May;25(5):776-84.
  • Modulation of PC1/3 Activity by Self-Interaction and Substrate Binding. Hoshino A, Kowalska D, Jean F, Lazure C, Lindberg I. (2011)  Endocrinology   Endocrinology.   Apr;152(4):1402-11.
  • Regulation of neuropeptide processing enzymes by catecholamines in endocrine cells.(2011) Helwig M, Vivoli M, Fricker LD, Lindberg I.  Mol Pharmacol.  Aug;80(2):304-13. E
  • Modulation of Prohormone Convertase 1/3 Properties Using Site-Directed Mutagenesis (2010) Ozawa A, Peinado JR, Lindberg I.  (2010) Endocrinology.   Sep;151(9):4437-45.
  • Deorphanization of novel peptides and their receptors. Ozawa A, Lindberg I, Roth B, Kroeze WK.  (2010)  AAPS J.   Sep;12(3):378-84
  • Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics (2009) Becker, G.L, Sielaff, F., Than, M.E., Lindberg I., Routhier, S., Day, R., Lu, Y., Garten, W., and Steinmetzer,T.  J Med Chem.  Feb 11;53(3):1067-75
  • A study of human furin specificity using synthetic peptides derived from natural substrates: effects of potassium ions (2009) Izidoro, M.A., Gouvea, I.E., Santos, J.A., Assis, D.M., Oliveira, V., Judice, W.A., Juliano, M.A., Lindberg, I,. and Juliano, L. Arch Biochem Biophys.487:105-14.
  • Enzymatic characterization of a human acyltransferase activity. (2009) Ozawa A, Speaker RB III, Lindberg I., E, PLoS ONE  4(5):e5426. Epub 2009 May 4.
  • Synthetic small-molecule prohormone convertase 2 inhibitors (2008) Kowalska D, Liu J, Appel JR, Ozawa A, Nefzi A, Mackin RB, Houghten RA, Lindberg I.  Mol Pharmacol. Dec 12, (2008)
  • Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. (2009)Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology March 2009
    • Ozawa A, Cai Y, Lindberg I., Production of bioactive peptides in an in vitro system, Anal Biochem. Apr 20, (2007)
    • Lee SN, Kacprzak MM, Day R, Lindberg I., Processing and trafficking of a prohormone convertase 2 active site mutant., Biochem Biophys Res Commun. Apr 13;355(3):825-9. (2007)
    • Waha A, Koch A, Hartmann W, Milde U, Felsberg J, Hubner A, Mikeska T, Goodyer CG, Sorensen N, Lindberg I., Wiestler OD, Pietsch T, Waha A. SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas. Oncogene Mar 5 (2007)
    • Lee SN, Peng B, Desjardins R, Pintar JE, Day R, Lindberg I. Strain-specific steroidal control of pituitary function.J Endocrinol. (2007) J. Endocrinol. 192(3):515-25.
    • Lee SN, Hwang JR, Lindberg I. Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. J Biol Chem. 2006 Feb 10;281(6):3312-20.
    • Kacprzak MM, Than ME, Juliano L, Juliano MA, Bode W, Lindberg I. Mutations of the PC2 substrate binding pocket alter enzyme specificity. J Biol Chem. 2005 Sep 9;280(36):31850-8.
    • Peinado JR, Laurent V, Lee SN, Peng BW, Pintar JE, Steiner DF, Lindberg I. Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes. Endocrinology. 2005 Aug;146(8):3438-44.
    • Henrich S, Lindberg I., Bode W, Than ME. Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J Mol Biol. 2005 Jan 14;345(2):211-27.
    • Lee SN, Prodhomme E, Lindberg I. Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS. J Endocrinol. 2004 Aug;182(2):353-64.
    • Peinado JR, Kacprzak MM, Leppla SH, Lindberg I. Cross-inhibition between furin and lethal factor inhibitors. Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5.
    • Kacprzak MM, Peinado JR, Than ME, Appel J, Henrich S, Lipkind G, Houghten RA, Bode W, Lindberg I. Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine. J Biol Chem. 2004 Aug 27;279(35):36788-94.
    • Sarac MS, Peinado JR, Leppla SH, Lindberg I. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan; 72(1): 602-5.
    • Peinado JR, Li H, Johanning K, Lindberg I. Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study. J Neurochem. 2003 Nov;87(4):868-78.
    • Laurent V, Jaubert-Miazza L, Desjardins R, Day R, Lindberg I. Biosynthesis of POMC-derived peptides in prohormone convertase 2 and 7B2 null mice. Endocrinology. 2003
    • Henrich S, Cameron A, Bourenkov GP, Kiefersauer R, Huber R, Lindberg I., Bode W, Than ME. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol. 2003 Jul;10(7):520-6.
    • Cornwall GA, Cameron A, Lindberg I., Hardy DM, Cormier N, Hsia N. The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2. Endocrinology. 2003 Mar;144(3):901-8.
    • Sarac MS, Cameron A, Lindberg I. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
    • Laurent V, Lindberg I. Mini-RIA: adaptation of conventional 125I-labeled radioimmunoassay to a 96-tube format. Anal Biochem. 2002 Oct 1;309(1):143.
    • Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I., Ugleholdt R, Holst JJ, Steiner DF. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10293-8.
    • Sarac MS, Zieske AW, Lindberg I. The lethal form of Cushing’s in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. Endocrinology. 2002 Jun;143(6):2324-32.
    • Sarac MS, Windeatt S, Castro MG, Lindberg I. Intrapituitary adenoviral administration of 7B2 can extend life span and reverse endocrinological deficiencies in 7B2 null mice. Endocrinology. 2002 Jun;143(6):2314-23.
    • Laurent V, Kimble A, Peng B, Zhu P, Pintar JE, Steiner DF, Lindberg I. Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3087-92.
    • Fortenberry Y, Hwang JR, Apletalina EV, Lindberg I. Functional characterization of ProSAAS: similarities and differences with 7B2. J Biol Chem. 2002 Feb 5;277(7):5175-86
    • Hwang JR, Lindberg I. Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site. J Neurochem. 2001 Oct;79(2):437-44.
    • Sayah M, Fortenberry Y, Cameron A, Lindberg I. Tissue distribution and processing of proSAAS by proprotein convertases. J Neurochem. 2001 Mar;76(6):1833-41
    • Muller L, Cameron A, Fortenberry Y, Apletalina EV, Lindberg I. Processing and sorting of the prohormone convertase 2 propeptide. J Biol Chem. 2000 Dec 15;275(50):39213-22.
    • Cameron A, Appel J, Houghten RA, Lindberg I. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.
    • Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. J Biol Chem. 2000 Jun 9;275(23):17886-93.
    • Cameron A, Fortenberry Y, Lindberg I. The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1. FEBS Lett. 2000 May 12;473(2):135-8.
    • Apletalina EV, Muller L, Lindberg I. Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide. J Biol Chem. 2000 May 12;275(19):14667-77.
    • Apletalina EV, Juliano MA, Juliano L, Lindberg I. Structure-function analysis of the 7B2 CT peptide. Biochem Biophys Res Commun. 2000 Jan 27;267(3):940-2.
    • Muller L, Zhu P, Juliano MA, Juliano L, Lindberg I. A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2. J Biol Chem. 1999 Jul 23;274(30):21471-7.
    • Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I., Leder P. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing’s disease. Cell. 1999 Mar 5;96(5):689-700.

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