Secretory Chaperones in Alzheimer’s disease- new paper

7B2 chaperone knockout in APP model mice results in reduced plaque burden. Jarvela TS, Womack T, Georgiou P, Gould TD, Eriksen JL, Lindberg I. Sci Rep. 2018 Jun 28;8(1):9813. doi: 10.1038/s41598-018-28031-7. PMID: 29955078

This paper shows that the loss of 7B2, like that of clusterin, has a paradoxical protective effect on brain amyloid deposition.